Demo

style.css
setup.css
index.html

section {
	display: grid;
	/* Give the implicit tracks a size. */
	grid-auto-rows: 80px;
	grid-auto-columns: 1fr;
}

div:nth-child(2) {
	grid-column: 2;
	grid-row: 4;
}

div:nth-child(3) {
	grid-column: 5;
	grid-row: 2;
}

div:last-child {
	grid-column: 6;
	grid-row: 6;
}

body {
	font-family: sans-serif;
	padding: 20px;
}

section {
	background-color: gold;
}

div {
	background-color: tomato;
	border-bottom: 2px solid firebrick;
	border-right: 2px solid firebrick;
	padding: 5px;
}

<!DOCTYPE html>
<html>
	<head>
		<meta name="viewport" content="width=device-width, initial-scale=1">
		<link href="/assets/styles/reset.css" rel="stylesheet">
		<link href="setup.css" rel="stylesheet">
		<link href="style.css" rel="stylesheet">
	</head>
	<body>
		<section>
			<div>
				<p>Item 1</p>
			</div>
			<div>
				<p>Item 2 <br>with line <br>breaks</p>
			</div>
			<div>
				<p>Item 3 <br>also</p>
			</div>
			<div>
				<p>Item 4</p>
			</div>
		</section>
	</body>
</html>